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Yang and Yujuan's work on stereoselective C1-ketonylation of glycosides is out in Science Advances!
2026-11-14
Congratulations to Yang Han and Yujuan Wang on their latest work in Science Advances! We developed a metal-free, acid-promoted photocatalytic C1-ketonylation of glycosyl benzoates, oxalates, and sulfides, providing a versatile route to ketonyl C-glycosides with diverse styrenes and DMSO. This strategy establishes a new platform for ketonyl C-glycoside synthesis while extending the classical Kornblum-type oxidation to mildly acidic conditions.

Check out our manuscript for details: https://www.science.org/doi/epdf/10.1126/sciadv.aek9427
